We are fortunate to have had a fantastic collaboration with the Marsden Lab at Stanford, mentoring graduate student Aaron Brown in the development of methods to create cardiac digital twins, i.e., a virtual replica of the human heart. Aaron recently defended his PhD thesis titled “Towards personalized multiphysics heart models for clinical applications“.
Some of the publications and preprints from this effort include,
Brown, Aaron L., Lei Shi, Matteo Salvador, Fanwei Kong, Daniel B. Ennis, Ian Chen, Vijay Vedula*, and Alison L. Marsden*. “Personalized biventricular mechanics and sensitivity to model morphology“, bioRxiv preprint bioRxiv:2025.12.11.693778 (2025). (*co-corresponding authors)
Brown, Aaron L., Matteo Salvador, Lei Shi, Martin R. Pfaller, Zinan Hu, Kaitlin E. Harold, Tzung Hsiai, Vijay Vedula*, and Alison L. Marsden*. “A Modular Framework for Implicit 3D-0D Coupling in Cardiac Mechanics. “Computer Methods in Applied Mechanics and Engineering 421 (2024): 116764. (*co-corresponding authors)
Aaron is also extending the framework to perform multiphysics fluid-structure interactions in the heart with applications to congenital heart disease, and gave a presentation at the 78th Annual Meeting of the APS Division of Fluid Dynamics in Houston, TX.

Congratulations, Aaron.

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